Portal de Periódicos da CAPES

Nerve growth factor and other neurotrophins in Alzheimer's disease

1994; Wiley; Volume: 9; Issue: 11 Linguagem: Inglês

10.1002/gps.930091102

1099-1166

Gordon Wilcock, David Dawbarn,

Alzheimer's disease research and treatments

International Journal of Geriatric PsychiatryVolume 9, Issue 11 p. 861-869 Editorial Review Nerve growth factor and other neurotrophins in Alzheimer's disease Gordon K. Wilcock, Gordon K. Wilcock University Department of Care of the Elderly, Frenchay Hospital, BristolSearch for more papers by this authorDavid Dawbarn, David Dawbarn University Department of Care of the Elderly, Frenchay Hospital, BristolSearch for more papers by this author Gordon K. Wilcock, Gordon K. Wilcock University Department of Care of the Elderly, Frenchay Hospital, BristolSearch for more papers by this authorDavid Dawbarn, David Dawbarn University Department of Care of the Elderly, Frenchay Hospital, BristolSearch for more papers by this author First published: November 1994 https://doi.org/10.1002/gps.930091102AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References Allen, S. J., Dawbarn, D. and Wilcock, G. K. (1988) Morphometric immunochemical analysis of neurons in the nucleus basalis of Meynert in Alzheimer's disease. Brain. Res. 454, 275–281. Allen, S. J., Dawbarn, D., Spillantini, M. G., et al. (1989) Distribution of β-nerve growth factor receptors in the human basal forebrain. J. Comp. Neurol. 289, 626–640. Allen, S. J., Dawbarn, D., MacGowan, S. H., Wilcock, G. K., Treanor, J. J. S. and Moss, T. H. (1990) A quantitative morphometric analysis of basal forebrain neurons expressing B-NGF receptors in normal and Alzheimer's disease brains. Dementia 1, 125–137. Allen, S. J., Dawbarn, D., Eckford, S. D., et al. (1994) Cloning of non-catalytic form of human trkb and distribution of mRNA for trkb in human brain. Neuroscience 60, 825–834. Aloe, L. (1990) Effect of adrenal gland hormones on NGF level and choline acetyltransferase activity in rat brain. Acta Neurobiol. Exp. Warsz. 50, 333–340. Arenas, E. and Persson, H. (1994)Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo. Nature 367, 371–375. Aschroft, M. A., Dawbarn, D., MacGowan, S. H., Allen, S. J., Feeney, R. and Colebrook, S. C. (1993) Expression of extracellular domains of p140trkA and p145trkB in insect cells. Soc. Neurosci. 538, 13. Batchelor, P. E., Armstrong, D. M., Blaker, S. N. and Gage, F. H. (1989) Nerve growth factor receptor and choline acetyltransferase colocalization in neurons within the rat forebrain: Response to fimbria-fornix transection. J. Comp. Neurol. 284, 187–204. Clos, J. and Legrand, C. (1990) An interaction between thyroid hormone and nerve growth factor promotes the development of hippocampus, olfactory bulbs and cerebellum: A comparative biochemical study of normal and hypothyroid rats. Growth Factors 3, 205–220. Colebrook, S. C., Feeney, R., MacGowan, S. H., Allen, S. J., Ashcroft, M. and Dawbarn, D. (1993) Construction of B-NGF. BDNF chimeric genes and expression of recombinant proteins. Brit. J. Pharm. 108, S P. 304. Dawbarn, D., Allen, S. J. and Semenko, F. M. (1988a) Immunohistochemical localization of B-nerve growth factor receptors in the forebrain of the rat. Brain Res. 440, 185–189. Dawbarn, D., Allen, S. J. and Semenko, F. M. (1988b) Coexistence of choline acetyltransferase and B-nerve growth factor receptors in the forebrain of the rat. Neurosci. Lett. 94, 138–144. Dawbarn, D., Colebrook, S. C., Feeney, R., MacGowan, S. H., Allen, S. J. and Ashcroft, M. (1993) Structure/activity relationships of NGF/BDNF chimeric proteins. Soc. Neurosci. Abs. 453.9, Ebendal, T. (1992) Function and evolution in the NGF family and its receptors. J. Neurosci. Res. 32, 461–470. Fischer, I., Richter-Landsberg, C. and Safaei, R. (1991) Regulation of microtubule associated protein 2 (MAP2) expression by nerve growth factor in PC12 cells. Exp. Cell Res. 194, 195–201. Fischer, W., Wictorin, A., Bjorkland, A., Williams, L. R., Varson, S. et al. (1987) Amelioration of cholinergic neuronal atrophy and spatial memory impairment in aged rats by NGF. Nature 329, 65–67. Friden, P. M., Walus, L. R., Watson, P., et al. (1992) Blood-brain barrier penetration and in vivo activity of an NGF conjugate. Science 259, 373–377. Gage, F. H., Armstrong, D. M., Williams, L. R. and Varon, L. (1988) Morphological response of axotomised septal meurones to nerve growth factor. J. Comp. Neurol. 269, 147–155. Garcia, E., Rios, C. and Sotelo, J. (1992) Ventricular injection of nerve growth factor increases dopamine content in the striata of MPTP-treated mice. Neurochem. Res. 17, 979–982. Giordano, T., Pan, J. B., Casuto, D., Watanabe, S. and Arneric, S. P. (1992) Thyroid hormone regulation of NGF, NT-3 and BDNF RNA in the adult rat brian. Brain Res. Mol. Brain Res. 16, 239–245. Goedert, M., Fine, A., Dawbarn, D., Wilcock, G. K. and Chao, M. V. (1989) Nerve growth factor receptor mRNA distribution in human brain: Normal levels in basal forebrain in Alzheimer's disease. Mol. Brain. Res. 5, 1–7. Hagg, T., Fass-Holmes, B., Vahlsing, H. L., Manthorpe, M., Conner, J. M. and Varon, S. (1989) Nerve growth factor (NGF) reverses axotomy-induced decreases in choline acetyltransferase, NGF receptor and size of medial septum cholinergic neurons. Brain Res. 505, 29–38. Hagg, T., Manthorpe, M., Vahlsing, H. L. and Varon, S. (1988) Delayed treatment with nerve growth factor reverses the apparent loss of cholinergic neurons after brain damage. Exp. Neurol. 101, 303–312. Hefti, F., Dravid, A. and Hartikka, J. (1984) Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septohippocampal lesions. Brain Res. 293, 305–311. Hefti, F., Hartikka, J., Eckenstein, F., Gnahn, H., Heumann, R. and Schwab, M. (1985) Nerve growth factor increases choline acetyltransferase but not survival or fibre growth of cultured septal neurones. Neuroscience 14, 55–68. Hefti, F. and Mash, D. C. (1989) Localisation of nerve growth factor receptors in the normal human brain and in Alzheimer's disease. Neurobiol. Aging 10, 75–87. Honnegar, P. and Lenior, D. (1982) Nerve growth factor stimulation of cholinergic telencephalic neurons in aggregating cell cultures. Dev. Brain Res. 3, 229–238. Hyman, C., Hofer, M., Barde, Y. A., et al. (1991) BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350, 230–232. Isaacson, L. G., Saffran, B. N. and Crutcher, K. A. (1990) Intracerebral NGF infusion induces hyperinnervation of cerebral blood vessels. Neurobiol. Aging 11, 51–55. Junard, E. O., Montero, C. N. and Hefti, F. (1990) Long-term administration of mouse nerve growth factor to adult rats with partial lesions of the cholinergic septohippocampal pathway. Exp. Neurol. 110, 25–38. Kaplan, D. R., Hempstead, B. L., Martin-Zanca, D., Chao, M. V. and Parada, L. F. (1991a) The trk protooncogene product: A signal transducing receptor for nerve growth factor [see comments]. Science 252, 554–558. Kaplan, D. R., Martin-Zanca, D. and Parada, L. F. (1991b) Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature 350, 158–160. Kerwin, J. M., Morris, C. M., Perry, R. H. and Perry, E. K. (1992) Hippocampal nerve growth factor receptor immunoreactivity in patients with Alzheimer's and Parkinson's disease. Neurosci. Lett. 143, 101–104. Kiss, J., McGovern, J. and Patel, A. J. (1988) Immunohistochemical localization of cells containing nerve growth factor receptors in the different regions of the adult rat forebrain. Neuroscience 27, .731.–.648. Klein, R., Jing, S. Q., Nanduri, V., O'Rourke, E. and Barbacid, M. (1991) The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65, 189–197. Klein, R., Silos-Santiago, I., Smeyne, R. J., et al. (1994) Disruption of the neurotrophin-3 receptor gene trkC eliminates Ia muscle afferents and results in abnormal movements. Nature 386, 249–251. Knusel, B., Beck, K. D., Winslow, J. W., et al. (1992) Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain. J. Neurosci. 12, 3491–4402. Knusel, B., Winslow, J. W., Rosenthal, A., et al. (1991) Promotion of central cholinergic and dopaminergic neuron differentation by brain-derived neurotrophic factor but not neurotrophin 3. Proc. Nat. Acad. Sci. USA 88, 961–965. Kordower, J. H., Gash, K. M., Bothwell, M., Hersh, L. and Mufson, E. J. (1989) Nerve growth factor receptor and choline acetyltransferase remain colocalised in the nucleus basalis (CH4) of Alzheimer's patients. Neurobiol. Aging 10, 67–74. Legrand, C. and Clos, J. (1991) Biochemical, immunocytochemical and morphological evidence for an interaction between thyroid hormone and nerve growth factor in the developing cerebellum of normal and hypothyroid rats. Dev. Neurosci. 13, 382–396. Levi-Montalcini, R. (1987) The nerve growth factor: Thirty-five years later. Embo. J. 6, 1145–1154. Madhok, T. C. and Sharp, B. M. (1992) Nerve growth factor enhances [3H] nicotine binding to a nicotinic cholinergic receptor on PC 12 cells. Endocrinology 130, 825–830. Martinex, H. J., Dreyfus, C. F., Jonakeit, M. and Black, I. B. (1985) Nerve growth factor promotes cholinergic development in brain striatal cultures. Proc. Nat. Acad. Sci. USA 82, 7777–7781. Maysinger, D., Jalsenjak, I. and Cuello, A. C. (1992) Microencapsulated nerve growth factor: Effects on the forebrain neurons following devascularizing cortical lesions. Neurosci. Lett. 140, 71–74. Merlio, J. P., Ernfors, P., Jaber, M. and Persson, J. (1992) Molecular cloning of rat trkC and distribution of cells expressing messenger RNAS for members of the trk family in the rat central nervous system. Neuroscience 51, 513–532. Milbrandt, J. (1988) Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene. Neuron. 1, 183–188. Mobley, W. C., Nerve, R. L., Prusiner, S. B. and McKinley, M. P. (1988) Nerve growth factor increases mRNA levels for the prion protein and the β-amyloid protein precursor in developing hamster brain. Proc. Nat. Acad. Sci. USA 85, 9811–9815. Mobley, W. C., Rutkowski, J. L., Tennekoon, G. I., Buchanan, K. and Johnston, M. V. (1986) Choline acetyltransferase activity in the striatum of neonatal rats increased by nerve growth factor. Science 229, 284–287. Mobley, W. C., Rutkowski, J. L., Tennekoon, G. I., Gemski, J., Buchanan, K. and Johnston, M. V. (1986b) Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurones. Brain Res. 387, 53–62. Olson, L., Nordberg, A., von Holst, H., et al. (1992) Nerve growth factor affects 11C-nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient (case report). J. Neural Transm. Park. Dis. Dement. Sect. 4, 79–95. Pearson, R. C. A., Sofroniew, M. V., Cuello, A. C., et al., (1983) Persistence of cholinergic neurones in the basal nucleus in a brain with senile dementia of Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase. Brain Res. 289, 375–379. Phillips, H. S., Hains, J. M., Armanini, M., Laramee, G. R., Johnson, S. A. and Winslow, J. W. (1991) BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron 7, 695–702. Refolo, L. M., Salton, S. R. J., Anderson, J. P., Metha, P. and Robakis, N. K. (1989) Nerve and epidermal growth factors induce the release of the Alzheimer amyloid precursor from PC12 cell cultures. Biochem. Biophys. Res. Commun. 164, 664–670. Schnell, L., Schneider, R., Kolbeck, R., Barde, Y-A. and Schwab, M. E. (1994) Neurotrophin-3 enhances sprouting of corticospinal tract during development and after spinal cord lesion. Nature 367, 170–173. Seckl, J. R., French, K. L., O'Donnell, D., et al. (1993) Glucocorticoid receptor gene expression is unaltered in hippocampal neurons in Alzheimer's disease. Brain Res. Mol. Brain Res. 18, 239–245. Seiler, M. and Schwab, M. E. (1984) Specific retrograde transport of nerve growth factor from neocortex to nucleus basalis in the rat. Brain Res. 300, 33–39. Strada, O., Hirsch, E. C., Javoy Agid, F., et al. (1992) Does loss of nerve growth factor receptors precede loss of cholinergic neurons in Alzheimer's disease? An autoradiographic study in the human striatum and basal forebrain. J. Neurosci. 12, 4766–4774. Stromberg, I., Wetmore, C. J., Ebendal, T., Ernfors, P., Persson, H. and Olson, L. (1990) Rescue of basal forebrain cholinergic neurons after implantation of genetically modified cells producing recombinant NGF. J. Neurosci. Res. 25, 405–411. Takei, N., Tsukui, H. and Hatanaka, H. (1988) Nerve growth factor increases the intracellular content of acetylcholine in cultured septal neurons from developing rats. J. Neurochem. 51, 1118–1125. Toran Allerand, C. D., Miranda, R. C., Bentham, W. D., et al. (1992) Estrogen receptors colocalize with lowaffinity nerve growth factor receptors in cholinergic neurons of the basal forebrain. Proc. Nat. Acad. Sci. USA 89, 4668–4672. Treanor, J. J. S., Dawbarn, D., Allen, S. J., MacGowan, S. H. and Wilcock, G. K. (1991) Low affinity nerve growth factor receptor binding in normal and Alzheimer's disease basal forebrain. Neurosci. Lett. 121, 73–76. Tuszyinski, M. H., Amaral, D. G. and Gage, F. H. (1990) Nerve growth factor infusion in the primate brain reduces lesion induced cholinergic neuronal degeneration. Neuroscience 10, 3604–3614. Williams, L. R., Varon, S., Peterson, G. M., Wictorin, K. and Fischer, W. (1986) Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria-fornix transection. Proc. Nat. Acad. Sci. ISA 83, 9231–9235. Zafra, F., Castren, E., Thoenen, H. and Lindholm, D. (1991) Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons. Proc. Nat. Acad. Sci. USA 88, 10037–10041. Zafra, F., Hengerer, B., Leibrock, J., Thoenen, H. and Lindholm, D. (1990) Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. Embo J. 9, 3545–3550. Zafra, F., Lindholm, D., Castren, E., Haritikka, J. and Thoenen, H. (1992) Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes. J. Neurosci. 12, 4793–4799. Volume9, Issue11November 1994Pages 861-869 ReferencesRelatedInformation