Portal de Periódicos da CAPES

Simian Varicella Virus Infects Ganglia before Rash in Experimentally Infected Monkeys

2001; Elsevier BV; Volume: 279; Issue: 1 Linguagem: Inglês

10.1006/viro.2000.0700

1096-0341

Ravi Mahalingam, Mary Wellish, Kenneth F. Soike, Tiffany White, Bette K. Kleinschmidt‐DeMasters, Donald H. Gilden,

Insect and Pesticide Research

Monkeys experimentally infected with simian varicella virus (SVV) develop rash 10–14 days later. However, the route and the time of ganglionic infection are unknown. Using PCR, we analyzed DNA extracted from tissues of 13 monkeys 5 to 60 days after either intratracheal or intravenous inoculation with SVV. SVV DNA was detected in ganglia from four of five monkeys sacrificed 6 to 7 days after intratracheal inoculation. Further, analysis of ganglia from monkeys sacrificed at 10 days revealed that intravenous inoculation produced a higher proportion of SVV DNA-positive ganglia (63%) than that after intratracheal inoculation (13%), pointing to the role of hematogenous spread in ganglionic infection. Like other organs, monkey ganglia become infected with SVV before the appearance of rash.