Portal de Periódicos da CAPES

Accessory molecules for Toll-like receptors and their function

2012; Nature Portfolio; Volume: 12; Issue: 3 Linguagem: Inglês

10.1038/nri3151

1474-1741

Clarissa C. Lee, Ana M. Avalos, Hidde L. Ploegh,

Antimicrobial Peptides and Activities

Toll-like receptors (TLRs) have a central role in the initiation of innate and adaptive immune responses. Recent studies have shown that various accessory molecules are required for the biosynthesis and/or activation of several TLRs. A detailed knowledge of these accessory molecules is necessary to better understand the function of TLRs in the immune system. Toll-like receptors (TLRs) are essential components of the innate immune system. Accessory proteins are required for the biosynthesis and activation of TLRs. Here, we summarize recent findings on TLR accessory proteins that are required for cell-surface and endosomal TLR function, and we classify these proteins based on their function as ligand-recognition and delivery cofactors, chaperones and trafficking proteins. Because of their essential roles in TLR function, targeting of such accessory proteins may benefit strategies aimed at manipulating TLR activation for therapeutic applications.