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Osteonecrosis of the Jaw in a Patient on Denosumab

2010; Elsevier BV; Volume: 68; Issue: 5 Linguagem: Inglês

10.1016/j.joms.2009.10.010

1531-5053

Tara Aghaloo, Alan L. Felsenfeld, Sotirios Tetradis,

Osteomyelitis and Bone Disorders Research

Osteonecrosis of the jaw (ONJ) presents clinically as exposed, necrotic bone in the maxilla or mandible of at least 8 weeks' duration, with or without the presence of pain, infection, or previous trauma in a patient who has not received radiation to the jaws. 1 Woo S.B. Hellstein J.W. Kalmar J.R. Narrative [corrected] review: Bisphosphonates and osteonecrosis of the jaws. Ann Intern Med. 2006; 144: 753 Crossref PubMed Scopus (1055) Google Scholar , 2 Shane E. Goldring S. Christakos S. et al. Osteonecrosis of the jaw: More research needed. J Bone Miner Res. 2006; 21: 1503 Crossref PubMed Scopus (86) Google Scholar , 3 Weitzman R. Sauter N. Eriksen E.F. et al. Critical review: Updated recommendations for the prevention, diagnosis, and treatment of osteonecrosis of the jaw in cancer patients—May 2006. Crit Rev Oncol/Hematol. 2007; 62: 148 Abstract Full Text Full Text PDF PubMed Scopus (160) Google Scholar Although necrotic bone exposure has been reported in the jaws of a variety of patients not receiving bisphosphonates (BPs), 4 Woodmansey K.F. White R.K. He J. Osteonecrosis related to intraosseous anesthesia: Report of a case. J Endod. 2009; 35: 288 Abstract Full Text Full Text PDF PubMed Scopus (11) Google Scholar , 5 Meer S. Coleman H. Altini M. et al. Mandibular osteomyelitis and tooth exfoliation following zoster-CMV co-infection. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101: 70 Abstract Full Text Full Text PDF PubMed Scopus (25) Google Scholar , 6 Pogrel M.A. Miller C.E. A case of maxillary necrosis. J Oral Maxillofac Surg. 2003; 61: 489 Abstract Full Text Full Text PDF PubMed Scopus (33) Google Scholar , 7 Farah C.S. Savage N.W. Oral ulceration with bone sequestration. Aust Dent J. 2003; 48: 61 Crossref PubMed Scopus (40) Google Scholar , 8 Glueck C.J. McMahon R.E. Bouquot J.E. et al. A preliminary pilot study of treatment of thrombophilia and hypofibrinolysis and amelioration of the pain of osteonecrosis of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998; 85: 64 Abstract Full Text PDF PubMed Scopus (38) Google Scholar , 9 Schwartz H.C. Osteonecrosis of the jaws: A complication of cancer chemotherapy. Head Neck Surg. 1982; 4: 251 Crossref PubMed Scopus (70) Google Scholar the number of BP-related ONJ cases has continued to increase steadily since the first report in 2003. 10 Marx R.E. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic. J Oral Maxillofac Surg. 2003; 61: 1115 Abstract Full Text Full Text PDF PubMed Scopus (2096) Google Scholar To date, a direct causal relationship between BP use and ONJ has not been established. 11 Tarassoff P. Csermak K. Avascular necrosis of the jaws: Risk factors in metastatic cancer patients. J Oral Maxillofac Surg. 2003; 61: 1238 Abstract Full Text Full Text PDF PubMed Scopus (152) Google Scholar , 12 Bone H.G. Hosking D. Devogelaer J.P. et al. Ten years' experience with alendronate for osteoporosis in postmenopausal women. N Engl J Med. 2004; 350: 1189 Crossref PubMed Scopus (1124) Google Scholar However, many retrospective and prospective analyses have identified cases of ONJ in which BP therapy, especially the more potent intravenous preparations, was the only consistent variable, strongly suggesting that BPs play a significant role in ONJ pathophysiology. 13 Odac M. Package insert revisions re: Osteonecrosis of the jaws: Zometa injection and Aredia injection. Package insert. 2005; Google Scholar , 14 Bamias A. Kastritis E. Bamia C. et al. Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: Incidence and risk factors. J Clin Oncol. 2005; 23: 8580 Crossref PubMed Scopus (965) Google Scholar , 15 Marx R.E. Sawatari Y. Fortin M. et al. Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: Risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg. 2005; 63: 1567 Abstract Full Text Full Text PDF PubMed Scopus (1257) Google Scholar , 16 Ruggiero S.L. Mehrotra B. Rosenberg T.J. et al. Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases. J Oral Maxillofac Surg. 2004; 62: 527 Abstract Full Text Full Text PDF PubMed Scopus (1609) Google Scholar , 17 Migliorati C.A. Bisphosphanates and oral cavity avascular bone necrosis. J Clin Oncol. 2003; 21: 4253 Crossref PubMed Scopus (429) Google Scholar , 18 Mortensen M. Lawson W. Montazem A. Osteonecrosis of the jaw associated with bisphosphonate use: Presentation of seven cases and literature review. Laryngoscope. 2007; 117: 30 Crossref PubMed Scopus (60) Google Scholar , 19 Zervas K. Verrou E. Teleioudis Z. et al. Incidence, risk factors and management of osteonecrosis of the jaw in patients with multiple myeloma: A single-centre experience in 303 patients. Br J Haematol. 2006; 134: 620 Crossref PubMed Scopus (249) Google Scholar , 20 Bagan J.V. Murillo J. Jimenez Y. et al. Avascular jaw osteonecrosis in association with cancer chemotherapy: Series of 10 cases. J Oral Pathol Med. 2005; 34: 120 Crossref PubMed Scopus (233) Google Scholar , 21 Clarke B.M. Boyette J. Vural E. et al. Bisphosphonates and jaw osteonecrosis: The UAMS experience. Otolaryngol Head Neck Surg. 2007; 136: 396 Crossref PubMed Scopus (40) Google Scholar , 22 Durie B.G. Katz M. Crowley J. Osteonecrosis of the jaw and bisphosphonates. N Engl J Med. 2005; 353: 99 Crossref PubMed Scopus (657) Google Scholar , 23 Khamaisi M. Regev E. Yarom N. et al. Possible association between diabetes and bisphosphonate-related jaw osteonecrosis. J Clin Endocrinol Metab. 2007; 92: 1172 Crossref PubMed Scopus (139) Google Scholar , 24 Pozzi S. Marcheselli R. Sacchi S. et al. Bisphosphonate-associated osteonecrosis of the jaw: A review of 35 cases and an evaluation of its frequency in multiple myeloma patients. Leuk Lymphoma. 2007; 48: 56 Crossref PubMed Scopus (78) Google Scholar