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Nonalcoholic fatty liver disease and aging: Epidemiology to management

2014; Baishideng Publishing Group; Volume: 20; Issue: 39 Linguagem: Inglês

10.3748/wjg.v20.i39.14185

2219-2840

Marco Bertolotti, Amedeo Lonardo, Chiara Mussi, Enrica Baldelli, Elisa Pellegrini, Stefano Ballestri, Dante Romagnoli, Paola Loria,

Diet, Metabolism, and Disease

Nonalcoholic fatty liver disease (NAFLD) is common in the elderly, in whom it carries a more substantial burden of hepatic (nonalcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma) and extra-hepatic manifestations and complications (cardiovascular disease, extrahepatic neoplasms) than in younger age groups.Therefore, proper identification and management of this condition is a major task for clinical geriatricians and geriatric hepatologists.In this paper, the epidemiology and pathophysiology of this condition are reviewed, and a full discussion of the link between NAFLD and the aspects that are peculiar to elderly individuals is provided; these aspects include frailty, multimorbid-