Inclusion Complexation and Solubilization of Paclitaxel by Bridged Bis(β-cyclodextrin)s Containing a Tetraethylenepentaamino Spacer
2003; American Chemical Society; Volume: 46; Issue: 22 Linguagem: Inglês
10.1021/jm034148f
ISSN1520-4804
AutoresYu Liu, Guosong Chen, Li, Heng‐Yi Zhang, Cao Dong-xu, Ying‐Jin Yuan,
Tópico(s)Protein purification and stability
ResumoA novel water-soluble paclitaxel complex has been prepared by inclusion complexation with bridged bis(β-cyclodextrin)s and characterized by means of 1H NMR, SEM, powder X-ray diffraction patterns, TG-DTA, DSC, FT-IR, and 2D NOESY. The cyclodextrins were able to solubilize paclitaxel to levels as high as 2 mg/mL. Furthermore, the cytotoxicity of the novel complexes was assessed using a K562 leukemia cell line which indicated that drug concentrations of 10 pg/mL elicited an inhibitory effect.
Referência(s)