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The Clinical Pharmacology of Antineoplastic Agents

1975; Massachusetts Medical Society; Volume: 292; Issue: 22 Linguagem: Inglês

10.1056/nejm197505292922206

1533-4406

Bruce A. Chabner, Charles E. Myers, C. Norman Coleman, David G. Johns,

Neuroblastoma Research and Treatments

Cytidine and Deoxycytidine AnaloguesThe pyrimidine nucleoside analogues cytosine arabinoside (cytarabine) and 5-azacytidine are of importance in the treatment of acute granulocytic leukemia. Although the former has been under active investigation for a decade, and now stands as one of the primary antileukemic agents, clinical experience with the latter in the United States has only begun to accumulate over the past three years, and its ultimate value in leukemia and solid tumors is not known at present. Both agents are analogues of naturally occurring nucleosides (Fig. 4); cytosine arabinoside is a 2-β-OH analogue of deoxycytidine and . . .