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BIBTEX RIS

Forecasting the economic value of an Enterovirus 71 (EV71) vaccine

2010; Elsevier BV; Volume: 28; Issue: 49 Linguagem: Inglês

10.1016/j.vaccine.2010.09.065

ISSN

1873-2518

Autores

Bruce Y. Lee, Angela R. Wateska, Rachel R. Bailey, Julie Tai-Schmiedel, Kristina M. Bacon, Kenneth J. Smith,

Tópico(s)

Animal Disease Management and Epidemiology

Resumo

Enterovirus 71 (EV71) is a growing public health concern, especially in Asia. A surge of EV71 cases in 2008 prompted authorities in China to go on national alert. While there is currently no treatment for EV71 infections, vaccines are under development. We developed a computer simulation model to determine the potential economic value of an EV71 vaccine for children (<5 years old) in China. Our results suggest that routine vaccination in China (EV71 infection incidence ≈0.04%) may be cost-effective when vaccine cost is $25 and efficacy ≥70% or cost is $10 and efficacy ≥50%. For populations with higher infection risk (≥0.4%), a $50 or $75 vaccine would be highly cost-effective even when vaccine efficacy is as low as 50%.

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