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Neomycin production by partial immobilization Streptomyces fradiae on cellulose beads in an air-lift bioreactor

1994; Elsevier BV; Volume: 78; Issue: 3 Linguagem: Inglês

10.1016/0922-338x(94)90303-4

1872-8073

Yong Soo Park, Noriyasu Ohta, Mitsuyasu Okabe,

Microbial Natural Products and Biosynthesis

An air-lift bioreactor was used for neomycin production by Streptomyces fradiae. The maximum neomycin concentration and viscosity were 1,176 mg/l and 49.8 cp, respectively. In order to improve the mixing characteristics of the culture broth, the mycelium was partially immobilized using cellulose beads by adding beads at a concentration of 0.75%, the maximum neomycin concentration was increased 1,600 mg/l while the viscosity was reduced to 37.3 cp.