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Oligosaccharides containing A (1–6) glycosidic linkage obtained from human blood-group specific glycoproteins

1968; Elsevier BV; Volume: 30; Issue: 1 Linguagem: Inglês

10.1016/0006-291x(68)90703-1

1090-2104

W.P. Aston, A.S.R. Donald, W. T. J. Morgan,

Amino Acid Enzymes and Metabolism

A, B, H, Lea and Leb blood-group active glycoproteins from human secretions and tissue fluids yield many di- and oligosaccharides on partial acid hydrolysis, alkaline degradation and hydrazinolysis. The evidence indicates that in the many carbohydrate chains in each specific substance there is a common pattern of alternate galactose and amino sugar units, but the mature of the glycosidic linkages between the different sugars is not always the same. It is firmly established that 1→3 and 1→4 linkages occur (see Watkins, 1966), and there is now evidence (Yosizawa, 1961. Lloyd and Kabat, 1967) for 1–6 linkages. In this communication the isolation from group specific glycoproteins of a disaccharide, a trisaccharide and a tetrasaccharide each containing a (1→6) linkage is described.