Artigo Revisado por pares

Direct Amide Synthesis from Either Alcohols or Aldehydes with Amines: Activity of Ru(II) Hydride and Ru(0) Complexes

2010; American Chemical Society; Volume: 75; Issue: 9 Linguagem: Inglês

10.1021/jo100254g

ISSN

1520-6904

Autores

Senthilkumar Muthaiah, Subhash Chandra Ghosh, Joo‐Eun Jee, Cheng Chen, Jian Zhang, Soon Hyeok Hong,

Tópico(s)

Synthetic Organic Chemistry Methods

Resumo

An in situ generated catalyst from readily available RuH2(PPh3)4, an N-heterocyclic carbene (NHC) precursor, NaH, and acetonitrile was developed. The catalyst showed high activity for the amide synthesis directly from either alcohols or aldehydes with amines. When a mixture of an alcohol and an aldehyde was reacted with an amine, both of the corresponding amides were obtained with good yields. Homogeneous Ru(0) complexes such as (η4-1,5-cyclooctadiene)(η6-1,3,5-cyclooctatriene)ruthenium [Ru(cod)(cot)] and Ru3(CO)12 were also active in the amidation of an alcohol or an aldehyde with the help of an in situ generated NHC ligand.

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