Direct Amide Synthesis from Either Alcohols or Aldehydes with Amines: Activity of Ru(II) Hydride and Ru(0) Complexes
2010; American Chemical Society; Volume: 75; Issue: 9 Linguagem: Inglês
10.1021/jo100254g
ISSN1520-6904
AutoresSenthilkumar Muthaiah, Subhash Chandra Ghosh, Joo‐Eun Jee, Cheng Chen, Jian Zhang, Soon Hyeok Hong,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoAn in situ generated catalyst from readily available RuH2(PPh3)4, an N-heterocyclic carbene (NHC) precursor, NaH, and acetonitrile was developed. The catalyst showed high activity for the amide synthesis directly from either alcohols or aldehydes with amines. When a mixture of an alcohol and an aldehyde was reacted with an amine, both of the corresponding amides were obtained with good yields. Homogeneous Ru(0) complexes such as (η4-1,5-cyclooctadiene)(η6-1,3,5-cyclooctatriene)ruthenium [Ru(cod)(cot)] and Ru3(CO)12 were also active in the amidation of an alcohol or an aldehyde with the help of an in situ generated NHC ligand.
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