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1-Pyrenol: A Biomarker for Occupational Exposure to Polycyclic Aromatic Hydrocarbons

1990; Taylor & Francis; Volume: 5; Issue: 5 Linguagem: Inglês

10.1080/1047322x.1990.10389643

1521-0898

William Tolos, Peter B. Shaw, Larry K. Lowry, Barbara A. MacKenzie, Jou‐Fang Deng, Harry L. Markel,

Occupational and environmental lung diseases

Abstract A biological monitoring method using the major urinary metabolite of pyrene, 1-pyrenol, has been successfully used to assess the exposure of aluminum reduction plant workers to coal tar pitch-derived polycyclic aromatic hydrocarbons (PAHs). The method used high-performance liquid chromatography with a fluorescence detector. The net mean change between workers pre- and postshift urinary 1-pyrenol concentrations was seventeenfold greater than the net mean change found in controls. The data strongly indicated that the net change in urinary 1-pyrenol concentration in workers was greater than found in controls. Evidence for an effect due to smoking in this context was negligible. The data show a strong positive correlation between environmental pyrene and all 17 environmental PAHs that were analyzed and urinary 1-pyrenol, verifying that pyrene was an appropriate choice to use as a marker for coal tar pitch-derived PAHs.