Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma
1989; Elsevier BV; Volume: 84; Issue: 1 Linguagem: Inglês
10.1016/0091-6749(89)90174-7
ISSN1097-6825
AutoresRussell A. Settipane, Donald D. Stevenson,
Tópico(s)Pharmacovigilance and Adverse Drug Reactions
ResumoDrugs inhibiting cyclooxygenase regularly cross-react with aspirin (ASA).Although some experiments suggest that acetaminophen (ACETM) is a weak inhibitor of cyclooxygenase in certain tissues, it has not been studied in human lung tissue, and controversy exists whether or not true cross-reactivity occurs between ASA and ACETM.Three ASA-sensitive subjects with asthma, who gave a history of reactions to ACETM, underwent double-blind, placebo-controlled challenges and reacted to 1000 mg of ACETM with a >20% fall in FEV,.Two patients were desensitized to ASA and then were rechallenged with 1000 mg of ACETM without reaction.Two patients were desensitized to increasing doses of ACETM, achieving refractoriness to 1500 mg, but not 2000 mg.Thus, cross sensitivity between ASA and ACETM was documented when large challenge doses (1000 mg) of ACETM were used.Furthermore, cross desensitization suggests that in ASA-sensitive subjects with asthma, similar mechanisms are likely to be responsible for reactions to ASA, nonsteroidal anti-intammatory drugs, and ACETM.(J ALLERGY CLIN IMMUNOL 1989;84:26-33 .)ACETM is a commonly used analgesic and antipyretic drug that is often used in place of ASA.Numerous publications have suggested that a small percentage of ASA-sensitive patients with asthma also react to ACETM.'-I4However, whether or not reported reactions are real and true cross-reactivity occurs continues to be controversial.Is Drugs, such as NSAIDs, which inhibit cyclooxygenase, are known to regularly cross-react with ASA.4.9, '5 However, animal experiments have demonstrated that ACETM, depending on the type of tissue studied, variably inhibits,'6-35 stimulates,".'9.35-4o or has no effect', "3 26.4'43 on cyclooxygenase.In tis-
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