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Antineoplastic Agents. 570. Isolation and Structure Elucidation of Bacillistatins 1 and 2 from a Marine Bacillus silvestris ,

2009; American Chemical Society; Volume: 72; Issue: 3 Linguagem: Inglês

10.1021/np800603u

1520-6025

George R. Pettit, John Knight, Delbert L. Herald, Robin K. Pettit, Fiona Hogan, M. Venugopal, John Hamblin, Michael J. Dodson, Jean-Charles Chapuis,

Chemical Synthesis and Analysis

Two new cyclodepsipeptides designated bacillistatins 1 (1) and 2 (2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI50's of 10−4−10−5 μg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.