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A clinical trial of the beta blocker propranolol in premature ejaculation

1984; Elsevier BV; Volume: 28; Issue: 4 Linguagem: Inglês

10.1016/0022-3999(84)90055-2

1879-1360

Alan Cooper, Ralph V. Magnus,

Urinary Bladder and Prostate Research

Twelve male patients, with a primary complaint of premature ejaculation in a setting of chronic anxiety with prominent somatic manifestations, participated in a double-blind trial: propranolol against placebo. The study consisted of 5 × 4 week phases: run-in, propranolol or placebo—120 mg/day allocated randomly, wash-out; placebo or propranolol and run-out, in a balanced design. Anxiety was rated initially, and every 2 weeks, throughout the trial using the Hamilton Rating Scale. Sitting blood pressure and pulse were also noted. The time to coital ejaculation (every 3 days) was recorded using a stopwatch, and subjects were also required to rate “overall coital satisfaction” and “quality of erection”. Neither prematurity nor other signs/symptoms of anxiety improved on the preparations, which were statistically equivalent. Moderate beta-blockade was achieved with propranolol as evidenced by a median reduction in pulse rate of 5 beats/min.