A New Prenylated Flavonol from the Root of Petalostemon purpureus
1996; American Chemical Society; Volume: 59; Issue: 3 Linguagem: Inglês
10.1021/np960068l
ISSN1520-6025
AutoresLi Huang, Fekadu Fullas, Robert McGivney, D. M. Brown, Mansukh C. Wani, Monroe E. Wall, John C. Tucker, Chris Beecher, John M. Pezzuto, A. Douglas Kinghorn,
Tópico(s)Chromatography in Natural Products
ResumoA new prenylated flavonol, petalopurpurenol (1), and a known dihydroflavonol, petalostemumol (2), have been isolated by DNA scission-guided fractionation of the organic portion of a 20% MeOH/CHCl3/H2O partition of a 50% MeOH/CHCl3 extract of the roots of Petalostemon purpureus. Compound 2 displayed moderate activity in DNA-scission assay. Both compounds 1 and 2 were evaluated for cytotoxicity in a panel of human cancer cell lines. The structures of petalopurpurenol (1) and petalostemumol (2) were determined by spectroscopic analysis.
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