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BIBTEX RIS

Ester derivatives of gallic acid with potential toxicity toward L1210 leukemia cells

2008; Elsevier BV; Volume: 16; Issue: 7 Linguagem: Inglês

10.1016/j.bmc.2008.01.049

1464-3391

Claudriana Locatelli, Rober Rosso, Maria Cláudia Santos‐Silva, Camila A. de Souza, Júlio Licinio, Paulo César Leal, Maria Luíza Bazzo, Rosendo Augusto Yunes, Tânia Beatriz Creczynski‐Pasa,

Natural product bioactivities and synthesis

Gallic acid and gallates with the same number of hydroxyl groups and varying the length of the side carbon chain, with respective lipophilicity being defined through the C log P values, were examined for their ability to induce apoptosis (through the DNA ladder fragmentation pattern), mitochondrial and cytoplasmic GSH depletion and NF-κB activation in murine lymphoblastic L1210 leukemia cells. A relationship between cytotoxic effect and a limited degree of lipophilicity was observed.