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Gamma-glutamyltranspeptidase levels as an aid in the management of human cancer

1983; Wiley; Volume: 52; Issue: 9 Linguagem: Inglês

10.1002/1097-0142(19831101)52

1097-0142

Daniel F. Sahm, J. Lee Murray, Peggy L. Munson, Robert E. Nordquist, Michael Lerner,

Asthma and respiratory diseases

CancerVolume 52, Issue 9 p. 1673-1678 ArticleFree Access Gamma-glutamyltranspeptidase levels as an aid in the management of human cancer Daniel F. Sahm PhD, Daniel F. Sahm PhD Department of Microbiology and Immunology, Oklahoma City, OklahomaSearch for more papers by this authorJ. Lee Murray MD, J. Lee Murray MD Department of Medicine University of Oklahoma Health Sciences Center, Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OklahomaSearch for more papers by this authorPeggy L. Munson, Peggy L. Munson Dean A. McGee Eye Institute, Oklahoma City, OklahomaSearch for more papers by this authorRobert E. Nordquist PhD, Robert E. Nordquist PhD Dean A. McGee Eye Institute, Oklahoma City, OklahomaSearch for more papers by this authorMichael P. Lerner PhD, Corresponding Author Michael P. Lerner PhD Department of Microbiology and Immunology, Oklahoma City, OklahomaDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190===Search for more papers by this author Daniel F. Sahm PhD, Daniel F. Sahm PhD Department of Microbiology and Immunology, Oklahoma City, OklahomaSearch for more papers by this authorJ. Lee Murray MD, J. Lee Murray MD Department of Medicine University of Oklahoma Health Sciences Center, Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OklahomaSearch for more papers by this authorPeggy L. Munson, Peggy L. Munson Dean A. McGee Eye Institute, Oklahoma City, OklahomaSearch for more papers by this authorRobert E. Nordquist PhD, Robert E. Nordquist PhD Dean A. McGee Eye Institute, Oklahoma City, OklahomaSearch for more papers by this authorMichael P. Lerner PhD, Corresponding Author Michael P. Lerner PhD Department of Microbiology and Immunology, Oklahoma City, OklahomaDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190===Search for more papers by this author First published: 1 November 1983 https://doi.org/10.1002/1097-0142(19831101)52:9 3.0.CO;2-UCitations: 13AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Plasma gamma-glutamyltranspeptidase (GGTP) levels were measured in 435 cancer patients, 120 healthy controls, 15 patients with systemic lupus erythematosis, and 10 patients with rheumatoid arthritis. The mean GGTP activity of all cancer patients studied, with the exception of malignant lymphoma, was significantly elevated compared to control values. Several patient groups were retrospectively analyzed to determine whether GGTP levels correlated with clinical status. Patients who were disease-free had GGTP levels in the normal range, whereas patients with metastases had elevated levels. Serially increasing GGTP levels were associated with disease progression and death. Persons who remained free of disease had serial GGTP levels within the normal range. Furthermore, decreasing levels were associated with response to therapy. 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