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Effect of clindamycin treatment on vaginal inflammatory markers in pregnant women with bacterial vaginosis and a positive fetal fibronectin test

2009; Elsevier BV; Volume: 107; Issue: 2 Linguagem: Inglês

10.1016/j.ijgo.2009.06.015

1879-3479

Laura Dı́az-Cueto, Pablo Domínguez-López, Gilberto Tena‐Alavez, Adrian Cuica‐Flores, Sergio Rosales-Ortíz, Fabián Arechavaleta-Velasco,

Reproductive System and Pregnancy

Abstract Objective To compare the levels of interleukin (IL)‐1β, IL‐6, and matrix metalloproteinase (MMP)‐8 in the vaginal secretions of pregnant women with a positive fetal fibronectin (fFN) test result with or without asymptomatic bacterial vaginosis (BV) before and after treatment with oral clindamycin. Methods A prospective cohort study was conducted among 43 pregnant women with a positive fFN test result. All patients were treated with clindamycin, and the pre‐ and post‐treatment levels of IL‐1β, IL‐6, and MMP‐8 were compared. Results Before treatment, levels of IL‐1β and MMP‐8 were significantly higher in women with BV compared with women without BV ( P < 0.05). Vaginal levels of IL‐1β and IL‐6, but not MMP‐8, decreased after treatment in pregnant women with BV. Conclusions The inability of clindamycin to decrease MMP‐8 vaginal levels may explain why it is ineffective in reducing preterm birth in pregnant women with positive fFN and BV.