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BIBTEX RIS

Aspirin to Prevent Gentamicin-Induced Hearing Loss

2006; Massachusetts Medical Society; Volume: 354; Issue: 17 Linguagem: Inglês

10.1056/nejmc053428

ISSN

1533-4406

Autores

Su Sha, Jian-Hua Qiu, Jochen Schacht,

Tópico(s)

Antimicrobial Peptides and Activities

Resumo

To the Editor: The use of aminoglycosides as powerful broad-spectrum, bactericidal, and nonallergenic antibiotics is limited by serious side effects, including irreversible hearing loss. Nevertheless, the drugs are commonly prescribed in some situations, including as part of the regimen against multidrug-resistant tuberculosis recommended by the World Health Organization.1 The incidence of gentamicin-induced hearing loss averages 8 percent for a short course of therapy2 but may be higher in developing countries, where aminoglycosides are frequently the only affordable antibiotics and are sold over the counter. No therapy presently exists to prevent ototoxicity. Animal models suggest that ototoxicity is caused by reactive . . .

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