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Correlation of Carotid Atheromatous Plaque Inflammation Using USPIO-Enhanced MR Imaging With Degree of Luminal Stenosis

2008; Lippincott Williams & Wilkins; Volume: 39; Issue: 7 Linguagem: Inglês

10.1161/strokeaha.107.504753

1524-4628

Tjun Yip Tang, Simon Howarth, Sam R. Miller, Martin J. Graves, Jean-Marie U-King-Im, Zhiyong Li, Stewart R. Walsh, Andrew J. Patterson, Peter J. Kirkpatrick, Elizabeth A. Warburton, K. Varty, Michael E. Gaunt, Jonathan H. Gillard,

Coronary Interventions and Diagnostics

Background and Purpose— Inflammation is a recognized risk factor for the vulnerable atherosclerotic plaque. The study explores the relationship between the degree of Magnetic Resonance (MR)–defined inflammation using Ultra Small Super-Paramagnetic Iron Oxide (USPIO) particles and the severity of luminal stenosis in asymptomatic carotid plaques. Methods— Seventy-one patients with an asymptomatic carotid stenosis of ≥40% underwent multi-sequence USPIO-enhanced MR imaging. Stenosis severity was measured according to the NASCET and ECST methods. Results— No demonstrable relationship between inflammation as measured by USPIO-enhanced signal change and the degree of luminal stenosis was found. Conclusions— Inflammation and stenosis are likely to be independent risk factors, although this needs to be further validated.