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T-cell dependent collagenous encapsulating response in the mouse liver to Mesocestoides corti (Cestoda)

1978; Elsevier BV; Volume: 8; Issue: 6 Linguagem: Inglês

10.1016/0020-7519(78)90064-4

1879-0135

Salvina Pollacco, W. L. Nicholas, Graham F. Mitchell, Aimorn C. Stewart,

Helminth infection and control

Pollacco S., Nicholas W.L., Mitchell G.F. and Chaicharn Stewart A. 1978. T-cell dependent collagenous encapsulating response in the mouse liver to Mesocestoides corti (Cestoda). International Journal for Parasitology8: 457–462. Experiments with genetically hypothymic mice show that the tetrathyridial larvae of Mesocestoides corti (Cestoda) multiply much more rapidly in the liver than in normal mice. In the hypothymic mouse, collagen fibres are not laid down and the parasite is not encapsulated as it is in the normal mouse. Encapsulation probably restricts the parasite's multiplication, and it is suggested that the failure to encapsulate the parasite accounts for its more rapid multiplication in the hypothymic mouse. Fibrogenesis and encapsulation is restored to hypothymic mice by transferring syngeneic thymus cells, spleen cells or peritoneal exudate cells. It is concluded that the encapsulation of M. corti is a T-cell dependent process.