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Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer

2003; Elsevier BV; Volume: 314; Issue: 1 Linguagem: Inglês

10.1016/j.bbrc.2003.12.079

1090-2104

Qing-Lin Li, Hye-Ryeon Kim, Wun‐Jae Kim, Joong-Kook Choi, Yong Hee Lee, Hwan-Mook Kim, Long Shan Li, Hoguen Kim, Joon Chang, Yoshiaki Ito, Kwang Youl Lee, Suk-Chul Bae,

Kruppel-like factors research

RUNX family transcription factors are integral components of TGF-β signaling pathways and have been implicated in cell cycle regulation, differentiation, apoptosis, and malignant transformation. It was noted previously that allele loss and loss of expression of RUNX3 are causally involved in gastric carcinogenesis. Our results demonstrate that RUNX3 is inactivated by aberrant DNA methylation in approximately 19% of lung cancer cell lines and 24% of primary lung cancer specimens. RUNX3 methylation is tumor-specific, since it is not observed in surrounding normal lung tissues. Our results suggest that loss of RUNX3 expression by DNA hypermethylation is frequently associated with the evolution of lung cancer.