Portal de Periódicos da CAPES

ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Somatostatin Receptor Imaging with ¹¹¹In-Pentetreotide

2009; Karger Publishers; Volume: 90; Issue: 2 Linguagem: Inglês

10.1159/000225946

1423-0194

Dirk Jan Kwekkeboom, Eric P. Krenning, Klemens Scheidhauer, Valerie Lewington, Rachida Lebtahi, A. Grossman, Pavel Vítek, Anders Sundin, Ursula Plöckinger, Göran Åkerström, Bruno Annibale, Rudolf Arnold, Emilio Bajetta, Jaroslava Barkmanova, Yuan Jia Chen, Frederico Costa, Anne Couvelard, Joseph Davar, Wouter W. de Herder, Gianfranco Delle Fave, Barbro Eriksson, Massimo Falconi, Diego Ferone, David J. Gross, Björn Gustafsson, Rudolf Hyrdel, Diana Ivan, Gregory Kaltsas, Réza Kianmanesh, Günter Klöppel, Ulrich Knigge, Paul Komminoth, Beata Kos‐Kudła, Anne Couvelard, Emmanuel Mitry, Ola Nilsson, Kjell Öberg, Juan Manuel O’Connor, Dermot O’Toole, Ulrich F. Pape, Mauro Papotti, Pavel Marianne, Aurel Perren, Marco Platania, Guido Rindi, Philippe Ruszniewski, Ramón Salazar, Aldo Scarpa, Jean‐Yves Scoazec, Waldemar Szpak, Babs G. Taal, Marie‐Pierre Vullierme, Bertram Wiedenmann,

Neuroblastoma Research and Treatments

scintigraphy with 111 In-pentetreotide, published by the Society of Nuclear Medicine [1] .99m Tc-Depreotide (Neotect ) is another commercially available somatostatin analog that has been approved specifically for the detection of lung cancer in patients with pulmonary nodules [2] .Because of the relatively high abdominal background and the impossibility of performing delayed imaging due to the short half-life of the tracer, it is less suited for the detection of abdominal neuroendocrine tumors [3] .Somatostatin is a regulatory peptide widely distributed in the human body, in particular in the central and peripheral nervous system, in the endocrine glands, in the immune system as well as in the gastrointestinal tract.In all these tissues, somatostatin action is mediated through membrane-bound receptors, of which five have been cloned (sst1-sst5) [4] .They all belong to the family of G-protein-coupled receptors.Only sst2, sst5 and, to some extent, sst3 have a high affinity for the commercially available synthetic octapeptide octreotide [5] .Somatostatin receptors are expressed in several normal human tissues, including brain, pituitary, gastrointestinal