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The Effects of Gonadotropin Treatment on the Immunological Features of Male Patients with Idiopathic Hypogonadotropic Hypogonadism

2000; Oxford University Press; Volume: 85; Issue: 1 Linguagem: Inglês

10.1210/jcem.85.1.6226

1945-7197

Zeki Yeşilova, Metin Özata, Ismail H. Kocar, Mustafa Turan, Aysel Pekel, Ali Şengül, I. Caglayan Ozdemír,

Adrenal Hormones and Disorders

There is a significant line of evidence for a role of androgens in the modulation of the immune system. However, little is known about immunological features of male patients with idiopathic hypogonadotropic hypogonadism (IHH) and the potential effects of gonadotropin treatment. Thus, the objective of this study was to evaluate the levels of selected soluble immune parameters [IgA, IgG, IgM, C3c, C4, interleukin-2 (IL-2), and IL-4], the CD4+/CD8+ ratio, and counts of total lymphocyte and some subpopulation of lymphocytes (CD3+, CD4+, CD8+, and CD19+ cells) before and after gonadotropin treatment in men with IHH. Twenty-nine IHH patients and 19 age-matched healthy controls were included in the study. The patients were treated with human menopausal gonadotropin/hCG for 6 months.