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Nuclear receptor regulation of cholesterol and bile acid metabolism

1999; Elsevier BV; Volume: 10; Issue: 6 Linguagem: Inglês

10.1016/s0958-1669(99)00031-2

1879-0429

Joyce J. Repa, David J. Mangelsdorf,

Peroxisome Proliferator-Activated Receptors

The metabolism of cholesterol and bile acids is transcriptionally regulated by classic feedforward and feedback signaling pathways. The mechanisms underlying this regulation have recently been elucidated by the characterization of three classes of orphan nuclear receptors. Furthermore, the study of these receptors suggests their potential as targets for new drug therapies.