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The uptake index method applied to studies on the blood‐retinal barrier II. Transport of several hexoses by a common carrier

1981; Wiley; Volume: 113; Issue: 1 Linguagem: Inglês

10.1111/j.1748-1716.1981.tb06865.x

1365-201X

Albert Alm, Per Törnquist, Olav Mäepea,

Drug Transport and Resistance Mechanisms

The uptake index method was used for studies on the passage of various monosaccharides across the blood‐retinal and the blood‐brain barriers in albino rats. The results indicate large similarities for the hexose transport through the two barriers. Thus a stereo‐specific, saturable transport of glucose was observed for both barriers. The carriers involved showed measurable affinity for 2‐deoxy‐D‐glucose, 3‐0‐methyl‐D‐glucose, D‐mannose and D‐galactose, but not for L‐glucose, D‐fructose or D‐ribose. The relative affinities of the various hexoses to the carriers were similar. Phloretin and phloridzin both reduced retinal and brain uptake of D‐glucose.