Portal de Periódicos da CAPES

The effect of Phe-Met-Arg-Phe-NH2 (FMRFamide) on morphine-induced inhibition of colonic propulsive motility in mice

1987; Elsevier BV; Volume: 83; Issue: 1-2 Linguagem: Inglês

10.1016/0304-3940(87)90228-x

1872-7972

Melissa B. Jacoby, Henry I. Jacoby, Joanne R. Mathiasen, Robert B. Raffa,

Pharmacological Receptor Mechanisms and Effects

Morphine and the molluscan neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) were administered to mice alone or in combination intracerebroventricularly (i.c.v.) and the effect on colonic propulsive motility was measured. Both morphine (1.0 μg, i.c.v.) and FMRFamide (10 and 50 μg, i.c.v.) delayed expulsion of a 3 mm glass bead placed in the distal colon of mice compared to vehicle-treated controls. The inhibitory effects of morphine and FMRFamide on expulsion time were additive at the doses used and individually blocked by naloxone. These data suggest that FMRFamide does not antagonize this non-analgesic effect of morphine, but appears to have opioid agonist properties.