Hrms: Current Usage, Future Directions And The Promise of Integration With Unified Data Streams Suited to Post-Acquisition Mining
2012; Future Science Ltd; Volume: 4; Issue: 5 Linguagem: Inglês
10.4155/bio.12.17
ISSN1757-6199
Autores Tópico(s)Analytical Chemistry and Chromatography
ResumoBioanalysisVol. 4, No. 5 CommentaryHRMS: current usage, future directions and the promise of integration with unified data streams suited to post-acquisition miningJonathan L JosephsJonathan L JosephsBristol-Myers Squibb. Research & Development, 311 Pennington Rocky Hill Road, Pennington, NJ 08534, USA. Published Online:12 Mar 2012https://doi.org/10.4155/bio.12.17AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: accurate massADMETbiotransformationhigh resolutionHRMSLC–MSmetabolismOrbitrapqualitative–quantitativeTOFReferences1 Fouda H, Nocerini M, Schneider R, Gedutis C. Quantitative analysis by high-performance liquid chromatography atmospheric pressure chemical ionization mass spectrometry: the determination of the renin inhibitor CP-80,794 in human serum. J. Am. Soc. Mass. 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Xenobiotica42(1),46–56 (2012).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByIdentification and quantification of TBBPA and its metabolites in adult zebrafish by high resolution liquid chromatography tandem mass spectrometryMicrochemical Journal, Vol. 154High-Resolution Accurate Mass Orbitrap and Its Application in Protein Therapeutics Bioanalysis2 June 2017From targeted quantification to untargeted metabolomics: Why LC-high-resolution-MS will become a key instrument in clinical labsTrAC Trends in Analytical Chemistry, Vol. 84Validation of the Mass-Extraction-Window for Quantitative Methods Using Liquid Chromatography High Resolution Mass Spectrometry23 February 2016 | Analytical Chemistry, Vol. 88, No. 6Unbiased Scanning Method and Data Banking Approach Using Ultra-High Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry for Quantitative Comparison of Metabolite Exposure in Plasma across Species Analyzed at Different Dates16 November 2015 | Analytical Chemistry, Vol. 87, No. 23Metabolomics-Based Approaches to Determine Drug Metabolite ProfilesAnalytical challenges for conducting rapid metabolism characterization for QIVIVEToxicology, Vol. 332Quantitative determination of azacitidine triphosphate in peripheral blood mononuclear cells using liquid chromatography coupled with high-resolution mass spectrometryJournal of Pharmaceutical and Biomedical Analysis, Vol. 90Screening and Characterization of Reactive Compounds with In Vitro Peptide-Trapping and Liquid Chromatography/High-Resolution Accurate Mass SpectrometrySLAS Discovery, Vol. 19, No. 2High-resolution MS: software, data processing and data management16 December 2014High-resolution MS: a future outlook16 December 2014Determination of rosiglitazone and 5-hydroxy rosiglitazone in rat plasma using LC–HRMS by direct and indirect quantitative analysis: a new approach for metabolite quantificationJian Jiang, Christopher A James & Philip Wong1 August 2013 | Bioanalysis, Vol. 5, No. 15Applications of high-resolution MS in bioanalysisMike-Qingtao Huang, Zhongping (John) Lin & Naidong Weng30 May 2013 | Bioanalysis, Vol. 5, No. 10Exploring the utility of high-resolution MS with post-acquisition data mining for simultaneous exogenous and endogenous metabolite profilingJoanna E Barbara, David B Buckley & Mark J Horrigan30 May 2013 | Bioanalysis, Vol. 5, No. 10The future key role of LC–high-resolution-MS analyses in clinical laboratories: a focus on quantificationBertrand Rochat, Emmanuel Kottelat & Justin McMullen17 December 2012 | Bioanalysis, Vol. 4, No. 24Direct bioanalytical sample injection with 2D LC–MSNM Cassiano, JC Barreiro, RV Oliveira & QB Cass4 December 2012 | Bioanalysis, Vol. 4, No. 22Utility of high-resolution accurate MS to eliminate interferences in the bioanalysis of ribavirin and its phosphate metabolitesCong Wei, James E Grace, Tatyana A Zvyaga & Dieter M Drexler3 September 2012 | Bioanalysis, Vol. 4, No. 15Quantitative/qualitative analysis using LC–HRMS: the fundamental step forward for clinical laboratories and clinical practiceBertrand Rochat9 August 2012 | Bioanalysis, Vol. 4, No. 14 Vol. 4, No. 5 STAY CONNECTED Metrics Downloaded 516 times History Published online 12 March 2012 Published in print March 2012 Information© Future Science LtdKeywordsaccurate massADMETbiotransformationhigh resolutionHRMSLC–MSmetabolismOrbitrapqualitative–quantitativeTOFFinancial & competing interests disclosureThe author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.PDF download
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