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Prevalence and role of a raised aldosterone to renin ratio in the diagnosis of primary aldosteronism: a debate on the scientific logic of the use of the ratio in practice

2003; Wiley; Volume: 59; Issue: 4 Linguagem: Inglês

10.1046/j.1365-2265.2003.01817.x

1365-2265

Paul L. Padfield,

Hormonal Regulation and Hypertension

Clinical EndocrinologyVolume 59, Issue 4 p. 422-426 Prevalence and role of a raised aldosterone to renin ratio in the diagnosis of primary aldosteronism: a debate on the scientific logic of the use of the ratio in practice Paul L. Padfield, Paul L. Padfield Consultant Endocrinologist/Reader in Medicine, Department of Medical Sciences, Western General Hospital, Edinburgh, UKSearch for more papers by this author Paul L. Padfield, Paul L. Padfield Consultant Endocrinologist/Reader in Medicine, Department of Medical Sciences, Western General Hospital, Edinburgh, UKSearch for more papers by this author First published: 18 September 2003 https://doi.org/10.1046/j.1365-2265.2003.01817.xCitations: 22 This manuscript is based upon a debate held at a Clinical Practice Summer School, Reading University, 12 July 2002. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References Baer, L., Brunner, H.R., Buhler, F. & Laragh, J.A. (1972) Pseudo-primary aldosteronism, a variant of low-renin essential hypertension?. In: Hypertension ′72 (eds J. Henest & E. Loiw), pp. 459–472. Springer Verlag, Berlin. Brown, J.J., Davies, D.L., Ferriss, J.B., Fraser, R., Haywood, E., Lever, A.F. & Robertson, J.I. 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(1999) Optimisation of antihypertensive treatment by cross-over rotation of four major classes. Lancet, 353, 2008–2013. Espiner, E.A. & Donald, R.A. (1980) Aldosterone regulation in primary aldosteronism: influence of salt balance, posture and ACTH. Clinical Endocrinology, 12, 277–286. Ferriss, J.B., Beevers, D.G., Brown, J.J., Fraser, R., Lever, A.F., Padfield, P.L. & Robertson, J.I.S. (1978) Low-renin ('primary') hyperaldosteronism differential diagnosis and distinction of subgroups within the syndrome. American Heart Journal, 95, 641–658. Ganguly, A. & Luetscher, J.A. (1976) Spironolactone therapy in primary aldosteronism: diagnostic and therapeutic implications. In: Systemic Effects of Antihypertensive Agents (ed. M.P. Sambhi), pp. 383–392. Stratton Intercontinental Medical Books, New York. Gordon, R.D., Stowasser, M., Klemm, S.A. & Tunny, T.J. (1994) Primary aldosteronism and other forms of mineralocorticoid hypertension. In: Textbook of Hypertension (ed. J. Swales), pp. 865–892. 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(2002) Primary aldosteronism, a common entity? The myth persists. Journal of Human Hypertension, 16, 159–162. Padfield, P.L., Beevers, D.G., Brown, J.J., Davies, D.L., Lever, A.F., Robertson, J.I.S. & Tree, M. (1975) Is low-renin hypertension a stage in the development of essential hypertension or a diagnostic entity? Lancet, 1, 548–550. Padfield, P.L., Brown, J.J., Davies, D.L., Fraser, R., Lever, A.F., Morton, J.J. & Robertson, J.I.S. (1981) The myth of idiopathic hyperaldosteronism. Lancet, 2, 83–84. Radin, D.R., Manoogian, C. & Nadicr, J.L. (1992) Diagnosis of primary hyperaldosteronism: importance of correlating CT findings with endocrinologic studies. American Journal of Roentgenology, 158, 553–557. Spark, R.F. & Melby, J.C. (1968) Aldosteronism in hypertension: the spironolactone response test. Annals of Internal Medicine, 169, 685–695. Stowasser, M. (2001) Primary aldosteronism: revival of a syndrome. Journal of Hypertension, 3, 363–366. Wisgerhof, M., Carpenter, P.C. & Brown, R.D. (1978) Increased adrenal sensitivity to angiotensin II in idiopathic hyperaldosteronism. Journal of Clinical Endocrinology and Metabolism, 47, 938–943. Young, W.F., Hogan, M.J., Klee, G.G., Grant, C.S. & Van Heerden, J.A. (1990) Primary aldosteronism: diagnosis and treatment. Mayo Clinic Proceedings, 65, 96–110. Citing Literature Volume59, Issue4October 2003Pages 422-426 ReferencesRelatedInformation