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A new method for rapid solution synthesis of shorter peptides by use of PyBOP®

1991; Elsevier BV; Volume: 32; Issue: 44 Linguagem: Inglês

10.1016/0040-4039(91)80176-7

1873-3581

Thomas Høeg-Jensen, Mogens Jakobsen, Arne Holm,

Receptor Mechanisms and Signaling

By using PyBOP® promoted coupling of Fmoc protected amino acids, and adopting the deprotection / washing procedure of the Fmoc Amino Acid Chloride Solution Technique (FAACST), a sample of [leucine5] enkephalin has been synthesized in a rapid, continuous solution phase method in 56% yield. The method is well applicable for the synthesis of large amounts of shorter peptide fragments.