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Aqueous Extracts of Lippia turbinata and Aloysia citriodora (Verbenaceae): Assessment of Antioxidant Capacity and DNA damage

2012; SAGE Publishing; Volume: 31; Issue: 2 Linguagem: Inglês

10.1177/1091581812436726

1092-874X

Erika Portmann, Marcela M. López Nigro, Claudia G. Reides, Susana Llesuy, Rafael A. Ricco, Marcelo L. Wagner, Alberto A. Gurni, Marta A. Carballo,

Carcinogens and Genotoxicity Assessment

The aim of the present work was to make a contribution to the knowledge of aqueous extracts of Lippia turbinata and Aloysia citriodora (Verbenaceae; infusion and decoction) in relation with the establishment of its antioxidant activity and lack of DNA damage, for its potential use in therapeutics. The cytogenotoxic profile was evaluated through genotoxic biomarkers such as mitotic index, cellular proliferation kinetics, sister chromatid exchanges, single-cell gel electrophoresis assay, and micronucleus test in human peripheral blood lymphocyte cultures. No statistical differences were found ( P > .05) between control and exposed cultures, even between both aqueous extracts. The total antioxidant capacity was shown to be higher in the decoction than in the infusion and both aqueous extracts protected against protein carbonylation and lipid peroxidation, the decoction being more efficient than the infusion ( P < .005). These results suggest the safe use of these medicinal plants as chemoecologic agents in therapeutics.