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Correlation between manual muscle strength and interleukin-6 (IL-6) plasma levels in elderly community-dwelling women

2008; Elsevier BV; Volume: 48; Issue: 3 Linguagem: Inglês

10.1016/j.archger.2008.02.012

1872-6976

Leani Souza Máximo Pereira, F.M.S. Narciso, Daniela Matos Garcia Oliveira, Fernanda Coelho, Danielle da Glória de Souza, Rosângela Corrêa Dias,

Muscle Physiology and Disorders

Sarcopenia is a loss of muscle mass related to aging and leads to muscle performance decline. An increase in inflammatory mediator levels, especially of IL-6, has been associated to reduced muscle strength in the elderly. The aim of the present cross-sectional study was to correlate IL-6 plasma levels with manual muscle strength (MMS) in 63 community-dwelling elderly women. (71.2+/-7.4years). IL-6 was measured using enzyme-linked immunosorbent assay (ELISA) and MMS was measured using the JAMAR dynamometer. Pearson's test was used to explore the relationship between the outcomes at the significance level of alpha=0.05. IL-6 levels (2.56+/-3.44pg/ml) and MMS (22.86+/-4.62kgf) exhibited an inverse correlation (r=-0.2673 and p=0.0373). The increase in IL-6 plasma levels possibly contributed toward the reduction in manual muscle strength among the elderly women studied.