Gram-Scale Synthesis of N -Aryl- and N -Aryl- N ′-methylpiperazines on a Novel, Water-Swellable, Oxethane-Linked Poly(ethylene glycol) High-Loading Resin
2005; Thieme Medical Publishers (Germany); Issue: 19 Linguagem: Inglês
10.1055/s-2005-918462
ISSN1437-210X
AutoresRobert J. Dancer, Hans Christian Rudbeck, I. Johannsen, O. Faurskov Nielsen, Thomas Ruhland, Michael Bech Sommer, David Tanner,
Tópico(s)Asymmetric Synthesis and Catalysis
ResumoA new methodology for the synthesis of N-arylpiperazines was developed using a poly(ethylene glycol)-derived solid support. The reactions proceeded in up to 60% overall yield over four steps. The scope and limitations of the method are discussed, as well as the utility of 13C gel-phase NMR spectroscopy for reaction monitoring.
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