Effect of Combined Sympathetic and Vagal Stimulation on Heart Rate in the Dog
1969; Lippincott Williams & Wilkins; Volume: 24; Issue: 4 Linguagem: Inglês
10.1161/01.res.24.4.567
ISSN1524-4571
AutoresH. R. Warner, Richard O. Russell,
Tópico(s)Neuroscience of respiration and sleep
ResumoHomeCirculation ResearchVol. 24, No. 4Effect of Combined Sympathetic and Vagal Stimulation on Heart Rate in the Dog Free AccessResearch ArticlePDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessResearch ArticlePDF/EPUBEffect of Combined Sympathetic and Vagal Stimulation on Heart Rate in the Dog HOMER R. WARNER and RICHARD 0. RUSSELLJr. HOMER R. WARNERHOMER R. WARNER Department of Biophysics and Bioengineering, The University of Utah Salt Lake City, Utah 84103 and RICHARD 0. RUSSELLJr.RICHARD 0. RUSSELLJr. Department of Biophysics and Bioengineering, The University of Utah Salt Lake City, Utah 84103 Originally published1 Apr 1969https://doi.org/10.1161/01.RES.24.4.567Circulation Research. 1969;24:567–573AbstractA set of equations is described which permit prediction of the time course of heart rate in a dog anesthetized with pentobarbital from the time course of frequency of stimuli applied to the distal cut ends of vagus and sympathetic efferent nerves to the heart. These equations, although based on assumptions as to the physiological mechanisms involved, were only tested for their ability to describe the kinetic relationship involved. The time course of heart rate resulting from combined vagus and sympathetic nerve stimulation (HRSV) is given by the equation:HRSV = HRV + (HRS - HR0) (HRV - HRmin)/(HR0 - HRmin), where the subscripted terms are heart rate values due to vagus stimulation (v), sympathetic stimulation (s), no stimulation (0) and the minimum (min) heart rate achievable by vagus stimulation alone. Clearly the vagus influence is capable of dominating the sympathetic in the control of heart rate. eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. 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