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High-resolution, lensless endoscope based on digital scanning through a multimode optical fiber

2013; Optica Publishing Group; Volume: 4; Issue: 2 Linguagem: Inglês

10.1364/boe.4.000260

2156-7085

Ioannis N. Papadopoulos, Salma Farahi, Christophe Moser, Demetri Psaltis,

Image Enhancement Techniques

We propose and experimentally demonstrate an ultra-thin rigid endoscope (450 μm diameter) based on a passive multimode optical fiber. We use digital phase conjugation to overcome the modal scrambling of the fiber to tightly focus and scan the laser light at its distal end. By exploiting the maximum number of modes available, sub-micron resolution, high quality fluorescence images of neuronal cells were acquired. The imaging system is evaluated in terms of fluorescence collection efficiency, resolution and field of view. The small diameter of the proposed endoscope, along with its high quality images offer an opportunity for minimally invasive medical endoscopic imaging and diagnosis based on cellular phenotype via direct tissue penetration.