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A 13C nmr and esr study on the structure of the different forms of the cobalt-bleomycin A2 complex

1980; Elsevier BV; Volume: 13; Issue: 2 Linguagem: Inglês

10.1016/s0162-0134(00)80119-1

1873-3344

Cornelis M. Vos, G. Westera, Dick Schipper,

Antibiotic Resistance in Bacteria

13C nmr and esr spectra have been recorded from oxygenated cobalt-bleomycin A2. It appears that (a) in oxygenated cobalt-bleomycin all the cobalt is in the Co3+ oxidation state, (b) the 13C nmr data indicate a structure of the Co-bleomycin complex in which the nitrogens of the pyrimidine, the imidazole, and the secondary and primary amine of the diaminopropanoic amide are involved as planar equatorial ligands, and (c) free bleomycin forms a "dimer" with Co-bleomycin.