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Synthesis of ( Z )-Ligustilide

1993; Taylor & Francis; Volume: 23; Issue: 20 Linguagem: Inglês

10.1080/00397919308012612

1532-2432

Shaobai Li, Zhiwei Wang, Xiaoping Fang, Yulin Li,

Neurological Disease Mechanisms and Treatments

Abstract The first synthesis of ligustilide (1) is described, starting from 2-formylbenzoic acid (2). The key step in synthesis is the Birch reduction of 3-hydroxybutyl-phthalide (4).