A New Approach to the Study of Human B Lymphocyte Function Using an Indirect Plaque Assay and a Direct B Cell Activator
1979; Wiley; Volume: 45; Issue: 1 Linguagem: Inglês
10.1111/j.1600-065x.1979.tb00272.x
ISSN1600-065X
Autores Tópico(s)Immune Cell Function and Interaction
ResumoImmunological ReviewsVolume 45, Issue 1 p. 41-67 A New Approach to the Study of Human B Lymphocyte Function Using an Indirect Plaque Assay and a Direct B Cell Activator A. Graham Bird, A. Graham Bird Department of Immunobiology, Karolinska Institute, Wallenberglaboratory Lilla Frescati, S-10405 Stockholm 50, Sweden.Department of Infectious Diseases, Danderyd Hospital, S-18203 Danderyd, Sweden.Search for more papers by this authorSven Britton, Sven Britton Department of Immunobiology, Karolinska Institute, Wallenberglaboratory Lilla Frescati, S-10405 Stockholm 50, Sweden.Department of Infectious Diseases, Danderyd Hospital, S-18203 Danderyd, Sweden.Search for more papers by this author A. Graham Bird, A. Graham Bird Department of Immunobiology, Karolinska Institute, Wallenberglaboratory Lilla Frescati, S-10405 Stockholm 50, Sweden.Department of Infectious Diseases, Danderyd Hospital, S-18203 Danderyd, Sweden.Search for more papers by this authorSven Britton, Sven Britton Department of Immunobiology, Karolinska Institute, Wallenberglaboratory Lilla Frescati, S-10405 Stockholm 50, Sweden.Department of Infectious Diseases, Danderyd Hospital, S-18203 Danderyd, Sweden.Search for more papers by this author First published: June 1979 https://doi.org/10.1111/j.1600-065X.1979.tb00272.xCitations: 145AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES Aarden, L., Coutinho, A. & Lefkovitz, I. (1977) Basel Institute for Immunology 1977 Annual Report, p. 71. Is TRF a mixture of specific factors?. Allison, A.C., Denman, A.M. & Barnes, R.D. (1971) Cooperating and controlling factors of thymus-derived lymphocytes in relation to autoimmunity. Lancet 2, 135. Andersson, J., Sjöberg, O. & Möller, G. (1972) Mitogens as probes for immunocyte activatioon and cooperation. Transpl. Rev. 11, 131. Bird, A.G. & Britton, S. (1979) A live human B cell activator operating in isolation of other cellular influences. Scand. J. Immunol. In press. Birnbaum, G. & Swick, L. (1978) Human suppressor lymphocytes. I. Induction and characterisation. Cell Immunol. 40, 16. Bretschner, P.A. & Cohn, M. (1968) Minimal model for the mechanism of antibody induction and paralysis by antigen. Nature 220, 444. Britton, S. (1976) Monocyte function in infectious mononucleosis: Evidence for a reversible cellular defect. J. Inf. Dis. 134, 395. Britton, S. (1978) Ups and downs in immune responsiveness during primary EB virus infection. In: Proceedings from Brook Lodge Conf. 1977. ed. B. Amos, In press. Brown, G. & Greaves, M. (1976) Cell surface markers for human T and B cells. Eur. J. Immunol. 4, 302. Coombs, R.R.A., Feinstein, A. & Wilson, A.B. (1969) Immunoglobulin determinants on the surface of human lymphocytes. Lancet ii, 1157. Cooper, M.D., Keightley, R.G., Wu, L.Y.F. & Lawton, A.R. (1973) Developmental defects of T and B cell lines in humans. Transpl. Rev. 16, 51. Coutinho, A. & Möller, G. (1975) Thymus-independent B cell induction and paralysis. Adv. Immunol. 21, 21. De Gast, G.C., The, T.H., Ponds, E. & Kallenberg, C. (1977) Suppression of DNA synthesis by Con A-activated human lymphocytes. Clin. Exp, Immunol. 30, 457. De La Concha, E.G., Oldham, G., Webster, A.D.B., Asherson, G.L. & Platts-Mills, T.A.E. (1977) Quantitative measurements of T and B cell function in 'variable' primary hypogammaglobulinaemia: Evidence for a consistent B cell defect. Clin. Exp. Immunol. 27, 208. Dickler, H.B. & Kunkel, H.G. (1972) Interaction of aggregated gammaglobulin with B lymphocytes. J. Exp. Med. 136, 191. Dosch, H.M., Percy, M.E. & Gelfand, E.W. (1977) Functional differentiation of B lymphocytes in congenital agammaglobulinaemia. I. Generation of haemolytic plaque forming cells. J. Immunol 119, 1959. Dutton, R.W. (1972) Inhibitory and stimulatory effects of Concanavalin A on the response of murine spleen suspensions to antigen. I. Characteristics of the inhibitory cell activity. J. Exp. Med 136, 1445. Eby, W.C., Chong, C.A., Dray, S. & Molinaro, G.A. (1975) Enumerating immunoglobulin secreting cells among peripheral human lymphocytes. A haemolytic plaque assay for a B cell function. J. Immunol. 115, 1700. Einhom, L. & Ernberg, I. (1978) Induction of EBNA precedes the first cellular S-phase after EBV infection of human lymphocytes. Int. J. Cancer 21, 157. Ekstedt, R.D., Waterfield, J.D., Nespoli, L. & Möller, G. (1977) Mechanism of action of suppressor cells. In vivo Con A-activated suppressor cells do not directly affect B cells. Scand. J. Immunol. 6, 247. Fauci, A.S. & Pratt, K.R. (1976a) Activation of human lymphocytes. I. Direct plaque forming cell assay for the measurement of polyclonal activation and antigenic stimulation of human B lymphocytes. J. Exp. Med. 144, 674. Fauci, A.S. & Pratt, K.R. (1976b) Polyclonal activation of bone marrow-derived lymphocytes from human peripheral blood measured by a direct plaque forming cell assay. Proc. Nat. Acad Sci. 73, 3676. Fauci, A.S., Pratt, K.R. & Whalen, G. (1976) Activation of human B lymphocytes. II. Cellular interactions in the PFC response of human tonsillar and peripheral blood B lymphocytes to polyclonal activation by pokeweed mitogen. J. Immunol. 117, 2100. Frøland, S.S. & Natvig, J. (1972) Surface-bound immunoglobulin on lymphocytes from normal and immunodeficient humans. Scand. J. Immunol. 1, 1. Fu, S.M., Winchester, R.J., Feizi, T., Walzer, P.D. & Kunkel, H.G. (1974) Idiotypic specificity of surface immunoglobulin and maturation of leukemic bone marrow-derived lymphocytes. Proc. Nat. Acad. Sci. 74, 4487. Ginsburg, W.C., Finkelman, F.D. & Lipsky, P.E. (1978) Circulating and mitogen-induced immunoglobulin secreting cells in human peripheral blood: Evaluation by a modified reverse haemolytic plaque assay. J. Immunol. 120, 33. Greaves, M.F., Janossy, G. & Doenhoff, M. (1974) Selective triggering of human T and B lymphocytes in vitro by polyclonal mitogens. J. Exp. Med. 140, 1. Gronowicz, E., Coutinho, A. & Melchers, F. (1976) A plaque assay for all cells secreting Ig of a given type or class. Eur. J. Immunol. 6, 588. Hammarström, L., Bird, A.G., Smith, C.I.E. & Britton, S. (1979) Pokeweed mitogen- induced differentiation of human B cells. Evaluation by a Protein A plaque assay. Immunology. In press. Haynes, B.F. & Fauci, A.S. (1977) Activation of human lymphocytes. III. Concanavalin A induced generation of suppressor cells of the plaque forming response of normal human B lymphocytes. J. Immunol. 118, 2281. Hayward, A.R. & Lawton, A.R. (1977) Induction of plasma cell differentiation of human lymphocytes: Evidence for functional immaturity of T and B cells. J. Immunol. 119, 1213. Henle, G., Henle, W. & Diehl, V. (1968) Relation of Burkitt's tumor associated herpes-type virus to infectious mononucleosis. Proc. Nat. Acad. Sci. 59, 94. Henle, G., Henle, W., Clifford, P., Diehl, V., Kafuko, G.W., Kurya, B.G., Klein, G., Morrow, G.H., Manube, G.M.R., Pike, P., Tukei, P.M. & Ziegler, K. (1969) Antibodies to Epstein-Barr virus in Burkitt lymphoma and control group. J. Nat. Cancer Inst. 43, 1147. Janossy, G. & Greaves, M.F. (1975) Functional analysis of murine and human B lymphocyte subsets. Transpl. Rev. 24, 177. Janossy, G., De la Concha, E., Luquetti, A., Snajdr, M.J., Waxdal, M.J. & Platts-Mills, T.A.E. (1977) T cell regulators of immunoglobulin synthesis and proliferation in pokeweed (Pa-I)-stimulated human lymphocyte cultures. Scand. J. Immunol. 6, 109. Jerne, N.K. & Nordin, A.A. (1963) Plaque forming in agar by single antibody producing cells. Science 140, 405. Jondal, M. (1974) Surface markers on human B and T lymphocytes. IV. Distribution of surface markers on resting and blast-transformed lymphocytes. Scand. J. Immunol. 3, 739. Jondal, M., Klein, G., Oldstone, M.B.A., Bokish, V. & Yefenof, E. (1976) Surface markers on human B and T lymphocytes. VIII. Association between complement and Ebstein-Barr virus receptors on human lymphoid cells. Scand. J. Immunol. 5, 401. Keightley, R.G., Cooper, M.D. & Lawton, A.R. (1976) The T cell dependence of B cell differentiation induced by pokeweed mitogen. J. Immunol. 117, 1538. Kennedy, J.C. & Axelrad, M.A. (1971) An improved assay for haemolytic plaque forming cells. Immunol. 20, 253. Klein, G., Svedmyr, E., Jondal, M. & Persson, P.E. (1976) EBV determined nuclear antigen (EBN A)-positive cells in the peripheral blood of infectious mononucleosis patients. Int. J. Cancer, 17, 21. Levin, A.G., Friberg, S. & Klein, E. (1968) Xenotransplantation of a Burkitt lymphoma culture line with surface immunoglobulin specificity. Nature 222, 997. Mangi, R.J., Niederman, J.C., Kelleher, J.E., Dwyer, J.M., Evans, A.S. & Kantor, F.S. (1974) Depression of cell-mediated immunity during acute infectious mononucleosis. New Engl. J. Med. 291, 1149. Mellstedt, H. & Pettersson, D. (1974) Lymphocyte subpopulations in chronic lymphocyte leukemia. Characterization by cell surface markers, cytotoxic activity and ontogenic stimulation. Scand. J. Immunol. 3, 303. Molinaro, G.A. & Dray, S. (1974) Antibody coated erythrocytes as a manifold probe for antigens. Nature 248, 515. Molinaro, G.A., Maron, E. & Dray, S. (1974) Antigen secreting cells; enumeration of immunoglobulin-allotype secreting cells in nonimmunised rabbits by means of hybrid antibody coated erythrocytes in a reverse haemoiytic plaque assay. Proc. Nat. Acad. Sci. 71, 1229. Möller, G. (1961) Demonstration of mouse isoantigens at a cellular level by the fluorescent antibody technique. J. Exp. Med. 114, 415. Olding, L.B. & Oldstone, M.B.A. (1974) Lymphocytes from human newborns abrogate mitosis of their mothers' lymphocytes. Nature 249, 161. Olding, L.B., Murgita, R.A. & Wigzell, H. (1977) Mitogen-stimulated lymphoid cells from human newborns suppress the proliferation of maternal lymphocytes across a cell- impermiable membrane. J. Immunol. 119, 1109. Oldstone, M.B.A., Tishon, A. & Moretta, L. (1977) Active thymus-derived suppressor lymphocytes in human cord blood. Nature 269, 333. Papamichael, M., Sheldon, P.J. & Holborow, E.J. (1974) T and B cell subpopulations in infectious mononucleosis. Clin. Exp. Immunol. 18, 1. Philips, B. & Roitt, I.M. (1973) Evidence for transformation of human B lymphocytes by PHA. Nature New Biol. 241, 256. Preudhomme, J.L., Gricelli, C. & Seligmann, M. (1973) Immunoglobulins on the surface of lymphocytes in 50 patients with primary immunodeficiency diseases. Clin. Immunol. Immunopath. 1, 241. Reedman, B.M. & Klein, G. (1973) Cellular localization of an Ebstein-Barr virus (EBV) associated complement fixing antigen in producer and nonproducer lymphoblastoid cell lines. Int. J. Cancer 11, 449. Robért, K.H., Möller, E., Gahrton, G., Ericksson, H. & Nilsson, B. (1978a) B cell activation of peripheral blood lymphocytes from patients with chronic lymphatic leukaemia. Clin. Exp. Immunol. 33, 302. Robért, K.H. (1978b) PHA-induced soluble factors can activate B cells from patients with chronic lymphatic leukaemia. Clin. Exp. Immunol. In press. Robért, K.H., Bird, A.G. & Möller, E. (1979) Mitogen-induced differentiation of human CLL lymphocytes to antibody secreting cells. Submitted for publication. Rosén, A., Gergely, P., Jondal, M., Klein, G. & Britton, S. (1977) Polyclonal Ig production after Ebstein-Barr virus infection of human lymphocytes in vitro. Nature 267, 52. Rowe, D.S., Hue, K., Forni, L. & Pernis, B. (1973) Immunoglobulin D as a lymphocyte receptor. J. Exp. Med. 138, 963. Schwartz, S.A., Shou, L., Good, R.A. & Yong, S.C. (1977) Suppression of immunoglobulin synthesis and secretion by peripheral blood lymphocytes from normal donors. Proc. Nat. Acad Sci. 74, 2099. Seligmann, M., Preud'homme, J.L. & Brouet, J.C. (1973) B and T cell markers in human proliferative blood diseases and primary immunodeficiencies with special reference lo membrane-bound immunoglobulins. Transpl Rev. 16, 85. Siegal, F.P., Siegal, M. & Good, R.A. (1978) Role of helper, suppressor and B cell defects in the pathogenesis of the hypogammaglobulinaemias. New Engl. J. Med. 299, 172. Steel, C.M., Philipson, J., Arthur, E., Gardiner, S.E., Newton, M.S. & McIntosh, R.V. (1977) Possibility of EB virus preferentially transforming a subpopulation of human B lymphocytes. Nature 270, 729. Steinitz, M., Klein, G., Koskimies, S. & Mäkelä, O. (1977) EB virus-induced B lymphocyte cell lines producing specific antibody. Nature 269, 420. Strelkausas, A.J., Callery, R.T., McDowell, J., Borel, Y. & Schlossmann, S.F. (1978) Direct evidence for loss of human suppressor cells during active autoimmune disease. Proc Nat. Acad. Sci. 75, 5150. Takada, K., Aya, T. & Osato, T. (1978) Early events in Ebstein-Barr virus-induced transformation of human lymphocytes studied by simultaneous observations of immunofluorescence, cellular morphology and autoradiography. In: Advances in Comparative Leukaemia Research 1977. ed. Bentuelzen et al. p. 212, Elsevier/North Holland Biomedical Press. Thorley-Lawson, D.A., Chess, L. & Strominger, J.L. (1977) Suppression of in vitro Epstein- Barr virus infection. A new role for adult human T lymphocytes. J. Exp. Med 146, 495. Vitetta, E.S. & Uhr, J.W. (1977) IgD and B cell differentiation. Immunol. Rev. 37, 50. Waldmann, T.A., Durm, M., Broder, S., Blackman, M., Blease, R.M. & Strober, W. (1974) Role of suppressor T cells in the pathogenesis of common variable hypogammaglobulinaemia. Lancet ii, 609. Wolf, H., Zur Hausen, H. & Becker, V. (1973) EB-viral genomes in epithelial nasopharangeal carcinoma cells. Nature New Biol. 244, 245. Wollheim, F.A. & Williams, R.C. (1966) Studies on the macroglobulins of human serum. I. Polyclonal immunoglobulin class M(IgM). Increases in infections mononucleosis New Engl. J. Med. 274, 61. Wu, L.Y.F., Blanco, A., Cooper, M.D. & Lawton, A.R. (1976) Ontogeny of B lymphocyte differentiation induced by pokeweed mitogen. Clin. Immunol. Immunopath. 5, 208. Citing Literature Volume45, Issue1June 1979Pages 41-67 ReferencesRelatedInformation
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