How the Listeria monocytogenes ActA protein converts actin polymerization into a motile force
1997; Elsevier BV; Volume: 5; Issue: 7 Linguagem: Inglês
10.1016/s0966-842x(97)01048-2
ISSN1878-4380
AutoresGregory A. Smith, Daniel A. Portnoy,
Tópico(s)Microbial Metabolism and Applications
ResumoThe ActA protein is an essential determinant of pathogenicity that is responsible for the actin-based motility of Listeria monocytogenes in mammalian cells and cell-free extracts. ActA appears to control at least four functions that collectively lead to actin-based motility: (1) initiation of actin polymerization, (2) polarization of ActA function, (3) transformation of actin polymerization into a motile force and (4) acceleration of movement mediated by the host protein profilin.
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