Methylmercury effects in rat, hamster, and squirrel monkey
1978; Elsevier BV; Volume: 15; Issue: 1 Linguagem: Inglês
10.1016/0013-9351(78)90073-7
ISSN1096-0953
Autores Tópico(s)Anesthesia and Neurotoxicity Research
ResumoThe LD5024 hours of methylmercury chloride was estimated as 11.9 mg/kg in the rat, 22.4 mg/kg in the hamster, and more than 17 mg/kg in the squirrel monkey. At 30 days, the LD50 was 10.1 mg/kg in the rat and 15.2 mg/kg in the hamster and was estimated as 4.7–6.4 mg/kg in the monkey. Motor symptoms such as hind-leg tucking when lifted by the tail were induced in the rat by five daily doses of 2 mg each, resulting in brain mercury levels above 8 μg/g of cerebral hemisphere or cerebellum, and more than 6 μ/g of pons and medulla. Levels of glycine, glutamate, aspartate, and γ-amino butyric acid (GABA) were unchanged from control levels. In monkeys, single doses of more than 3 mg/animal and five doses of 0.75 mg or more produced a neurological degenerative pattern at mercury levels greater than 8 μg/g of tissue. GABA was increased and glycine, glutamate, and aspartate were decreased in the brain tissue. Neither single nor repeated doses produced motor responses in the hamster prior to death.
Referência(s)