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Design of β-sheet systems for understanding the thermodynamics and kinetics of protein folding

2004; Elsevier BV; Volume: 14; Issue: 4 Linguagem: Inglês

10.1016/j.sbi.2004.06.001

1879-033X

Mark S. Searle, Barbara Ciani,

Chemical Synthesis and Analysis

Peptide β-sheet systems have emerged as context-independent models for probing secondary structure propensities, the nature and magnitude of stabilizing weak interactions, and aspects of cooperativity both parallel and perpendicular to the strand direction. These systems have allowed fundamental advances in understanding non-covalent interactions relevant to both chemical and biological systems, and in describing the protein folding energy landscape.