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BIBTEX RIS

Toxicological studies on Stryphnodendron adstringens

2002; Elsevier BV; Volume: 83; Issue: 1-2 Linguagem: Inglês

10.1016/s0378-8741(02)00219-2

1872-7573

Marcelo Alessandro Rebecca, Emy Luiza Ishii‐Iwamoto, Renata Grespan, Roberto Kenji Nakamura Cuman, Silvana Martins Caparroz‐Assef, João Carlos Palazzo de Mello, Ciomar Aparecida Bersani-Amado,

Natural Compound Pharmacology Studies

This study was carried out to determine the acute toxicity of total barbatimão extract (LD(50)) after oral administration to mice, and its effect on certain biochemical parameters in plasma of rats after 30 days of administration. The LD(50) value of the extract was 2699 mg/kg. A daily oral administration of extracts at 800 and 1600 mg/kg doses for 30 days caused a decrease in body weight, thymic involution, and an increase of plasma glucose and aspartate aminotransferase levels in the animals. The results showed that the extract administered in a prolonged period produced toxic effects in the experimental animals.