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Artigo Revisado por pares
BIBTEX RIS

Synthesis and anti-HIV activity of 2′-fluorine modified nucleoside phosphonates: Analogs of GS-9148

2007; Elsevier BV; Volume: 18; Issue: 3 Linguagem: Inglês

10.1016/j.bmcl.2007.11.126

ISSN

1464-3405

Autores

Richard L. Mackman, Kuei‐Ying Lin, Constantine G. Boojamra, Hon C. Hui, Janet L. Douglas, Deborah Grant, Oleg V. Petrakovsky, Vidya Prasad, Adrian S. Ray, Tomáš Cihlář,

Tópico(s)

HIV Research and Treatment

Resumo

Modified purine analogs of GS-9148 [5-(6-amino-purin-9-yl)-4-fluoro-2,5-dihydro-furan-2-yloxymethyl]-phosphonic acid (2'-Fd4AP) were synthesized and their anti-HIV potency evaluated. The antiviral activity of guanosine analog (2'-Fd4GP) was comparable that of to 2'-Fd4AP in MT-2 cells, but selectivity was reduced.

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