Portal de Periódicos da CAPES

Hypoglycaemic and antihyperglycaemic activity of <i>Ageratum conyzoides</i> l. In rats.

2010; African Traditional Herbal Medicine Supporters Initiative (ATHMSI); Volume: 6; Issue: 2 Linguagem: Inglês

10.4314/ajtcam.v6i2.57083

2505-0044

Nyemb Nyunaï, Njifutié Njikam, E Abdenneb, Joseph T Mbafor, Driss Lamnaouer,

Biochemical Acid Research Studies

The hypoglycaemic and antihyperglycaemic properties of the aqueous extracts of the leaves of Ageratum conyzoides L. were evaluated in normoglycemic and in streptozotocin-induced diabetic rats, in order to validate its use in folk medicine. Tested animals were given the aqueous extracts of the plant at the doses of 100, 200 and 300mg/kg. These doses were tested also on glucose loaded normal male rats (Oral Glucose Tolerance Test). Of all the doses, the aqueous extracts at 200 and 300mg/kg showed statistically significant hypoglycaemic and antihyperglycaemic activities. For the oral glucose tolerance test, 100mg/kg dose only attenuated significantly the rise of blood glucose in normal fasted rats. Consequently, these results confirmed the hypoglycaemic properties of the leaves of Ageratum conyzoides.Key word: Ageratum conyzoides, hypoglycaemic activity, antihyperglycaemic activity, Oral glucose tolerancetest.