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Short synthesis of protease inhibitors via modified Passerini condensation of N-Boc-α-aminoaldehydes

2002; Elsevier BV; Volume: 43; Issue: 22 Linguagem: Inglês

10.1016/s0040-4039(02)00728-1

1873-3581

Luca Banfi, Giuseppe Guanti, Renata Riva, Andrea Basso, Emiliano Calcagno,

Click Chemistry and Applications

Extension of the previously reported modification of Passerini multicomponent reaction (involving condensation with N-Boc-α-aminoaldehydes followed by a deprotection–transacylation step) to α-aminoacid derived carboxylic or isocyanide components, allowed the highly convergent and short synthesis of complex peptidomimetic structures, including known potent inhibitors of serine proteases.