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The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice

2010; Elsevier BV; Volume: 48; Issue: 5 Linguagem: Inglês

10.1016/j.molimm.2010.12.002

1872-9142

Philippe Georgel, Mirjana Radosavljevic, Cécile Macquin, Seiamak Bahram,

Immunotherapy and Immune Responses

As opposed to the well established role of MHC-linked, polymorphic, class I (MHC-I) genes in adaptive immunity, a universal role for non-conventional MHC-I is unknown, thus requiring a case-by-case study. The MHC unlinked, monomorphic, but β2microglobulin (β2m)-associated “MHC class I related” MR1 molecule interacts with a semi-invariant TCR. The pathophysiology of this interaction or more importantly of this peculiar MHC-I remains mostly unknown. Recently it was shown that β2m deficient mice were more susceptible to infection by Klebsiella pneumoniae, a widely spread Gram-negative bacteria that causes diverse and often severe ailments in man. Here we demonstrate, using both an in vivo imaging system and survival tests, the increased susceptibility to K. pneumoniae (but not to several other Gram negative bacteria) of MR1 deficient mice. This is accompanied by a consequent change in body temperature and systemic cytokine profile. Hence MR1 controls K. pneumoniae infection in vivo.