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Protective immunity and eosinophilia in IgE-deficient SJA/9 mice infected with Nippostrongylus brasiliensis and Trichinella spiralis.

1988; National Academy of Sciences; Volume: 85; Issue: 12 Linguagem: Inglês

10.1073/pnas.85.12.4460

1091-6490

Naohiro Watanabe, Ken Katakura, Akio Kobayashi, Ko Okumura, Zoltán Óváry,

Animal Genetics and Reproduction

To elucidate the roles of IgE antibody in host responses to helminth infection, selective IgE-deficient SJA/9 mice were infected with the nematode parasites Nippostrongylus brasiliensis, which elicits remarkable potentiated IgE production, and Trichinella spiralis, which induces strong anti-Trichinella IgE antibody production in normal mice. The kinetics of blood eosinophilia, worm burden after primary infection, and resistance to secondary infection in SJA/9 mice were the same in both infections as those in congenic SJL/J mice used as an IgE-producing control. These results indicate that the host responses examined here operate under IgE-independent mechanisms.