Portal de Periódicos da CAPES

Cancer‐promoting tumor‐associated macrophages: New vistas and open questions

2011; Wiley; Volume: 41; Issue: 9 Linguagem: Inglês

10.1002/eji.201141894

1521-4141

Alberto Mantovani, Giovanni Germano, Federica Marchesi, Marco Locatelli, Subhra K. Biswas,

Immune Cell Function and Interaction

Abstract Tumor‐associated macrophages (TAMs) are key components of the tumor macroenvironment. Cancer‐ and host cell‐derived signals generally drive the functions of TAMs towards an M2‐like polarized, tumor‐propelling mode; however, when appropriately re‐educated. TAMs also have the potential to elicit tumor destructive reactions. Here, we discuss recent advances regarding the immunobiology of TAMs and highlight open questions including the mechanisms of their accumulation (recruitment versus proliferation), their diversity and how to best therapeutically target these cells.