Plasma carotenoid, α-tocopherol and retinol concentrations and risk of colorectal adenomas: A case-control study in Japan
2005; Elsevier BV; Volume: 226; Issue: 2 Linguagem: Inglês
10.1016/j.canlet.2005.03.040
ISSN1872-7980
AutoresJing Jiang, Sadao Suzuki, Jin Xiang, Kiyonori Kuriki, Akihiro Hosono, Kazuyuki Arakawa, Jingwen Wang, Teruo Nagaya, Masayo Kojima, Nobuyuki Katsuda, Shinkan Tokudome,
Tópico(s)Retinoids in leukemia and cellular processes
ResumoTo investigate associations between plasma carotenoids, α-tocopherol and retinol with colorectal adenomas risk, we measured concentrations in 224 asymptomatic colorectal adenoma cases and 230 population-based controls matched for age and sex. After adjustment for age, history of colorectal adenomas and cancers, BMI, smoking, drinking status, multivitamin consumption and plasma total cholesterol, the risk of colorectal adenomas in the highest quartile was approximately half of that of men in the lowest quartile for α-carotene (OR=0.38; 95% CI: 0.18–0.84; Ptrend=0.01), β-carotene (OR=0.51; 95% CI: 0.24–1.07; Ptrend=0.03) and total carotenoids (OR=0.48; 95% CI: 0.22–1.03; Ptrend=0.04). In addition, a protective association for α-carotene in women was also indicated, but which did not reach statistical significance (OR=0.53; 95% CI: 0.19–1.52; Ptrend=0.35). Our findings suggest a protective effect of carotenoids against the development of colorectal adenomas.
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